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KMID : 0616620050110010037
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Journal of Soonchunhyang Medical College
2005 Volume.11 No. 1 p.37 ~ p.43
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Two Cases of Persistent Gestational Trophoblastic Disease after Complete Hydatidiform Mole
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Lee Jin-Hee
Ryu Eun-Seok
Kim Yun-Sook
Kim Jong-Soo
Choi Seung-Do
Sunwoo Jae-Gun
Bae Dong-Han
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Abstract
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Persistent tumor develops in approximately 20% of patients with a complete mole, and chemotherapy is required to achieve remission. Following evacuation of hydatidiform mole, careful hCG monitoring is mandatory since it is the most reliable and sensitive method for the early detection of gestational trophoblastic disease. In carefully selected patients in whom the risk of developing gestational trophoblastic disease is significant or when the availability of hCG testing is suboptimal, chemoprophylaxis has been shown to decrease the risk of gestational trophoblastic tumor. We report here two cases of patient, 16-year-old and 45-year-old women who experienced unusual course after the evacuation of a complete mole and markedly elevated serum β-hCG levels. The patient developed persistent gestational trophoblastic disease and were successfully treated with EMA-CO and hysterectomy.
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KEYWORD
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Complete hydatidiform mole, Persistent gestational trophoblastic disease, Chemotherapy, Hysterectomy
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